Fotobiomodulación con luz verde y su impacto sobre la viabilidad y proliferación de fibroblastos dérmicos humanos en condiciones de glucosa variable
S.Franco-Pastrana, T.Spezzia-Mazzocco
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Información básica
Volumen
V58 - N1 / 2025 Especial: Óptica y Fotónica en México
Referencia
51204
DOI
http://dx.doi.org/10.7149/OPA.58.1.51204
Idioma
English
Etiquetas
Fotobiomodulación, alta concentración de glucosa, fibroblastos, luz verde.
Resumen
La fotobiomodulación (PBM) con luz verde ha despertado un creciente interés, aunque sus efectos siguen siendo controvertidos, especialmente en cuanto a sus mecanismos de acción y condiciones de dosis óptimas. Este estudio reporta por primera vez, el impacto de la exposición a luz verde sobre fibroblastos dérmicos humanos, cultivados en concentraciones normales y altas de glucosa, utilizando diferentes dosis de irradiación (0.125 J/cm2, 0.25 J/cm2, 0.5 J/cm2 y 2 J/cm2). Los resultados muestran una disminución dependiente de la dosis en la viabilidad celular, siendo la reducción más significativaa 2 J/cm2, especialmente bajo condiciones de glucosa normal. A pesar de estos efectos en la viabilidad celular, no se observaron cambios significativos en la proliferación celular, lo que sugiere que la PBM no impactó la tasa general de proliferación bajo las condiciones experimentales. Estos hallazgos contribuyen a una mayor comprensión de los efectos de la PBM con luz verde y destacan la influencia de la concentración de glucosa en las respuestas celulares, aunque se requiere más investigación para esclarecer los mecanismos involucrados y optimizar los parámetros terapéuticos en tratamientos basados en fibroblastos.
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