Métodos polarimétricos para la mejora de imágenes en aplicaciones biológicas

Albert Van Eeckhout


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Información básica

Volumen

V57 - N3 / 2024 Ordinario

Referencia

51181

DOI

http://dx.doi.org/10.7149/OPA.57.3.51181

Idioma

Spanish

Etiquetas

Polarimetría, Tejidos biológicos, Despolarización, Biomedicina, Técnicas de Imagen, Matriz de Mueller, Clasificación de tejidos, Plantas

Resumen

Este artículo resume el trabajo de investigación llevado a cabo por el autor en el Grupo de Óptica de la Universitat Autònoma de Barcelona (UAB) para la realización de la Tesis Doctoral "Polarimetric methods for the image enhancement in biological applications" dirigida por el Dr. Ángel Lizana Tutusaus y el Cat. Juan Campos Coloma. En ella se estudia, por primera vez, la implementación experimental de una serie de métodos polarimétricos para mejorar el análisis y la visualización de tejidos biológicos, tejidos animales y vegetales. Se ha investigado la relación entre los dos principales grupos de técnicas polarimétricas, las Puertas de Polarización (del inglés Polarization Gating) y las técnicas basadas en la medida de la matriz de Mueller, y se ha propuesto un nuevo método para obtener Puertas de Polarización en base a medidas de una única matriz de Mueller. Debido a que, hasta el momento, el análisis de la despolarización de la luz en estudios biomédicos se restringe al uso de observables globales, se analiza el interés de utilizar en dicho contexto los Índices de Pureza Polarimétrica, que son un grupo de observables que describen con más detalle las propiedades de despolarización de la muestra. Estos se aplican a la inspección de tejidos de origen animal, permitiendo mejorar la visualización de tejidos, revelando ciertas estructuras ocultas en canales de despolarización estándar, y también mejorando la eficiencia al clasificar diferentes tipos de tejido. También se estudia el uso de la polarimetría en tejidos de origen vegetal, ámbito en el que las técnicas basadas en la matriz de Mueller son escasamente utilizadas. Por ello, los estudios con muestras de origen vegetal se centran en el potencial de la polarimetría de Mueller, obteniendo como resultado información complementaria, o incluso superior en ciertos casos, a otras técnicas ópticas no polarimétricas.

Referencias

1

A. R. Kherlopian, T. Song, Q. Duan, M. A. Neimark, M. J. Po, J. K. Gohagan, A. F. Laine, "A review of imaging techniques for systems biology," BMC Syst. Biol. (2008).

2

R. Carriles, D. N. Schafer, K. E. Sheetz, J. J. Field, R. Cisek, V. Barzda, A. W. Sylvester, J. A. Squier, "Invited Review Article: Imaging techniques for harmonic and multiphoton absorption fluorescence microscopy," Rev. Sci. Instrum. (2009).

3

S. Jacquemoud, S. Ustin, Leaf Optical Properties (Cambridge University Press, 2019).

4

V. V. Tuchin, Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis: Third Edition. SPIE Press, Bellingham (2015).

5

V. V. Tuchin, L. V. Wang, D. A. Zimnyakov, Optical Polarization in Biomedical Applications. Springer, Berlin (2006).

6

L. Rey-Barroso, F. J. Burgos-Fernández, X. Delpueyo, M. Ares, S. Royo, J. Malvehy, S. Puig, M. Vilaseca, "Visible and extended near-infrared multispectral imaging for skin cancer diagnosis," Sensors (2018).

7

L. van Manen, J. Dijkstra, C. Boccara, E. Benoit, A. L. Vahrmeijer, M. J. Gora, J. S. D. Mieog, "The clinical usefulness of optical coherence tomography during cancer interventions," J. Cancer Res. Clin. Oncol. (2018).

8

O. Maiques, M. Georgouli, V. Sanz-Moreno, "Recent advances in tissue imaging for cancer research," F1000Research (2019).

9

V. Singh, N. Sharma, S. Singh, "A review of imaging techniques for plant disease detection," Artif. Intell. Agric. (2020).

10

C. Farber, M. Mahnke, L. Sanchez, and D. Kurouski, "Advanced spectroscopic techniques for plant disease diagnostics. A review," TrAC - Trends Anal. Chem. (2019).

11

E. Vilaprinyo, T. Puig, M. Rue, "Contribution of early detection and adjuvant treatments to breast cancer mortality reduction in Catalonia, Spain," PLoS One (2012).

12

R. C. N. van den Bergh, S. Loeb, M. J. Roobol, "Impact of Early Diagnosis of Prostate Cancer on Survival Outcomes," Eur. Urol. Focus (2015).

13

S. Savary, A. Ficke, J. N. Aubertot, C. Hollier, "Crop losses due to diseases and their implications for global food production losses and food security," Food Secur. (2012).

14

C. J. R. Sheppard, "Microscopy: Phase Contrast Microscopy," in Encyclopedia of Modern Optics, Five-Volume Set (2004).

15

A. Peinado, A. Lizana, J. Campos, "Design of polarimeters based on liquid crystals and biaxial crystals for polarization metrology," Opt. Pura y Apl. (2016).

16

M. Shinki, M. T. Ivanov, J. S. Post, S. Vagle, J. T. Cullen, D. K. Hore, "Autocalibrating Stokes polarimeter for materials characterization," Appl. Opt. (2012).

17

P. Li, D. Lv, H. He, H. Ma, "Separating azimuthal orientation dependence in polarization measurements of anisotropic media," Opt. Express (2018).

18

N. Uribe-Patarroyo, A. Alvarez-Herrero, R. L. Heredero, J. C. Del Toro Iniesta, A. C. López Jiménez, V. Domingo, J. L. Gasent, L. Jochum, V. Martínez Pillet, "IMaX: A polarimeter based on liquid crystal variable retarders for an aerospace mission," in Physica Status Solidi (C) Current Topics in Solid State Physics (2008).

19

J. Hough, "Polarimetry: A powerful diagnostic tool in astronomy," Astron. Geophys. (2006).

20

J. S. Tyo, D. L. Goldstein, D. B. Chenault, J. A. Shaw, "Review of passive imaging polarimetry for remote sensing applications," Appl. Opt. (2006).

21

A. S. Alenin, L. Morrison, C. Curiel, J. S. Tyo, "Hyperspectral measurement of the scattering of polarized light by skin," in Polarization Science and Remote Sensing V (2011).

22

F. Vasefi, N. MacKinnon, R. B. Saager, A. J. Durkin, R. Chave, E. H. Lindsley, D. L. Farkas, "Polarization-sensitive hyperspectral imaging in vivo: A multimode dermoscope for skin analysis," Sci. Rep. (2014).

23

E. Gnanatheepam, U. Kanniyappan, K. Dornadula, A. Prakasarao, G. Singaravelu, "Polarization gating technique extracts depth resolved fluorescence redox ratio in oral cancer diagnostics," Photodiagnosis Photodyn. Ther. (2020).

24

A. N. Yaroslavsky, X. Feng, A. Muzikansky, M. R. Hamblin, "Fluorescence Polarization of Methylene Blue as a Quantitative Marker of Breast Cancer at the Cellular Level," Sci. Rep. (2019).

25

T. Yasui, Y. Tohno, T. Araki, "Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetry," J. Biomed. Opt. (2004).

26

B. Yang, P. Y. Lee, Y. Hua, B. Brazile, S. Waxman, F. Ji, Z. Zhu, I. A. Sigal, "Instant polarized light microscopy for imaging collagen microarchitecture and dynamics," J. Biophotonics (2020).

27

J. Chue-Sang, Y. Bai, S. Stoff, M. Gonzalez, J. Gomes, A. Gandjbakhche, V. V. Chernomordik, J. C. Ramella-Roman, "Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy," in Diagnosis and Treatment of Diseases in the Breast and Reproductive System (2017).

28

J. Qi, D. S. Elson, "Mueller polarimetric imaging for surgical and diagnostic applications: a review," J. Biophotonics (2017).

29

V. M. Turzhitsky, A. J. Gomes, Y. L. Kim, Y. Liu, A. Kromine, J. D. Rogers, M. Jameel, H. K. Roy, V. Backman, "Measuring mucosal blood supply in vivo with a polarization-gating probe," Appl. Opt. (2008).

30

M. P. Siegel, Y. L. Kim, H. K. Roy, R. K. Wali, V. Backman, "Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy," Appl. Opt. (2006).

31

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M.-R. Antonelli, A.-D. Martino, "Polarimetric imaging of uterine cervix: a case study," Opt. Express (2013).

32

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, H. Ma, "Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues," J. Biomed. Opt. (2014).

33

P. Schucht, H. R. Lee, H. M. Mezouar, E. Hewer, A. Raabe, M. Murek, I. Zubak, J. Goldberg, E. Kövari, A. Pierangelo, T. Novikova, "Visualization of White Matter Fiber Tracts of Brain Tissue Sections with Wide-Field Imaging Mueller Polarimetry," IEEE Trans. Med. Imaging (2020).

34

M. Kupinski, M. Boffety, F. Goudail, R. Ossikovski, A. Pierangelo, J. Rehbinder, J. Vizet, T. Novikova, "Polarimetric measurement utility for pre-cancer detection from uterine cervix specimens," Biomed. Opt. Express (2018).

35

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, I. Meglinski, "Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media," J. Biophotonics (2015).

36

L. Graham, Y. Yitzhaky, and I. Abdulhalim, "Classification of skin moles from optical spectropolarimetric images: a pilot study," J. Biomed. Opt. (2013).

37

S. P. Morgan, I. M. Stockford, "Surface-reflection elimination in polarization imaging of superficial tissue," Opt. Lett. (2003)

38

J. M. Bueno, "Measurement of parameters of polarization in the living human eye using imaging polarimetry," Vision Res. (2000).

39

K. M. Twietmeyer, R. A. Chipman, A. E. Elsner, Y. Zhao, D. VanNasdale, "Mueller matrix retinal imager with optimized polarization conditions," Opt. Express (2008).

40

V. N. Du Le, I. Saytashev, S. Saha, P. F. Lopez, M. Laughrey, J. C. Ramella-Roman, "Depth-resolved Mueller matrix polarimetry microscopy of the rat cornea," Biomed. Opt. Express (2020).

41

P. G. Ellingsen, M. B. Lilledahl, L. M. S. Aas, C. de L. Davies, M. Kildemo, "Quantitative characterization of articular cartilage using Mueller matrix imaging and multiphoton microscopy," J. Biomed. Opt. (2011).

42

M. K. Swami, S. Manhas, P. Buddhiwant, N. Ghosh, A. Uppal, P. K. Gupta, "Polar decomposition of 3 x 3 Mueller matrix: a tool for quantitative tissue polarimetry," Opt. Express (2006).

43

S. Sridhar and A. Da Silva, "Enhanced contrast and depth resolution in polarization imaging using elliptically polarized light," J. Biomed. Opt. (2016).

44

J. J. Gil Pérez, R. Ossikovski, Polarized Light and the Mueller Matrix Approach, CRC Press, Boca Raton (2016).

45

D. H. Goldstein, Polarized Light: Third Edition. CRC Press, Boca Raton (2017).

46

S.-Y. Lu, R. A. Chipman, "Interpretation of Mueller matrices based on polar decomposition," J. Opt. Soc. Am. A 13(5), 1106–1113 (1996).

47

E. Zeiger, P. K. Hepler, "Production of Guard Cell Protoplasts from Onion and Tobacco," Plant Physiol. (1976).

48

I. Shtein, Y. Shelef, Z. Marom, E. Zelinger, A. Schwartz, Z. A. Popper, B. Bar-On, S. Harpaz-Saad, "Stomatal cell wall composition: Distinctive structural patterns associated with different phylogenetic groups," Ann. Bot. (2017).

49

V. Bischoff, S. Nita, L. Neumetzler, D. Schindelasch, A. Urbain, R. Eshed, S. Persson, D. Delmer, W. R. Scheible, "TRICHOME BIREFRINGENCE and its homolog AT5G01360 encode plant-specific DUF231 proteins required for cellulose biosynthesis in arabidopsis," Plant Physiol. (2010).

50

R. L. Long, M. P. Bange, S. G. Gordon, G. A. Constable, "Measuring the Maturity of Developing Cotton Fibers using an Automated Polarized Light Microscopy Technique," Text. Res. J. (2010).

51

S. V. Berdyugina, J. R. Kuhn, D. M. Harrington, T. Šantl-Temkiv, E. J. Messersmith, "Remote sensing of life: Polarimetric signatures of photosynthetic pigments as sensitive biomarkers," in International Journal of Astrobiology (2016).

52

V. C. Vanderbilt, L. Grant, C. S. T. Daughtry, "Polarization of Light Scattered by Vegetation," Proc. IEEE (1985).

53

V. I. Kharuk, V. V. Yegorov, "Polarimetric indication of plant stress," Remote Sens. Environ. (1990).

54

F. Stabo-Eeg, D. Letalick, O. Steinvall, M. Lindgren, "Discriminating land mines from natural backgrounds by depolarization," in Electro-Optical Remote Sensing, Photonic Technologies, and Applications II (2008).

55

P. J. Curran, "Polarized visible light as an aid to vegetation classification," Remote Sens. Environ. (1982).

56

I. San José, J. J. Gil, "Invariant indices of polarimetric purity: Generalized indices of purity for n × n covariance matrices," Opt. Commun. (2011).

57

A. Van Eeckhout, “Polarimetric methods for the image enhancement in biological applications,” Tesis de doctorado, Universitat Autònoma de Barcelona (2021)

58

G. G. Stokes, “On the compoisition and resolution of streams of polarised light from different sources,” Trans. Cambridge Philos. Soc. (1852).

59

H. Mueller, “The foundation of optics,” J. Opt. Soc. Am. (1948).

60

A. Lizana, A. Van Eeckhout, K. Adamczyk, C. Rodríguez, J. C. Escalera, E. Garcia-Caurel, I. Moreno, J. Campos, “Polarization gating based on Mueller matrices,” J. Biomed. Opt. (2017).

61

A. Van Eeckhout, A. Lizana, E. Garcia-Caurel, J. J. Gil, R, Ossikovski, J. Campos, “Synthesis and characterization of depolarizing samples based on the indices of polarimetric purity,” Opt. Lett. (2017).

62

A. Van Eeckhout, J. J. Gil, E. Garcia-Caurel, J. García Romero, R. Ossikovski, I. Moreno, J. Campos, A. Lizana, “Unravelling physical information of depolarizers,” Opt. Express (2021).

63

A. Van Eeckhout, A. Lizana, E. Garcia-Caurel, J. J. Gil, A. Sansa, C. Rodríguez, I. Estévez, E. González, J. C. Escalera, I. Moreno, J. Campos, “Polarimetric imaging of biological tissues based on the indices of polarimetric purity,” J. Biophotonics (2017).

64

A. Van Eeckhout, E. Garcia-Caurel, R. Ossikovski, A. Lizana, C. Rodríguez, E. González-Arnay, J. Campos, “Depolarization metric spaces for biological tissues classification,” J. Biophotonics (2020).

65

A. Van Eeckhout, E. Garcia-Caurel, T. Garnatje, M. Durfort, J. C. Escalera, J. Vidal, J. J Gil, J. Campos, A. Lizana, “Depolarizing metrics for plant samples imaging,” PloS one (2019).

66

A. Van Eeckhout, E. Garcia-Caurel, T. Garnatje, J. C. Escalera, M. Durfort, J. Vidal, J. J. Gil, J. Campos, A. Lizana, “Polarimetric imaging microscopy for advanced inspection of vegetal tissues,” Sci. Rep (2021).