Predictive analysis of photodynamic treatment depth with different photosensitizer based nanocarriers
F. Fanjul-Vélez, I. Salas-García, J. L. Arce-Diego
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Base Information
Volume
V49 - N2 / 2016 Ordinario
Reference
75-82
DOI
http://dx.doi.org/10.7149/OPA.49.2.48537
Language
Spanish
Keywords
Nanoparticles, photosensitizer, carcinoma, Photodynamic Therapy, optical propagation.
Abstract
The effect of gold nanoparticles to deliver different types of photosensitizer used in Photodynamic Therapy on the depth of light penetration is studied by means of a predictive model with dosimetric purposes. The model employed allows to analyze the changes induced by the spherical nanoparticles administration in the optical distribution within the malignant tissue. The depth of photodynamic treatment was estimated in a nodular basal cell carcinoma taking into account both the conventional photosensitizer delivery and by means of nanoparticles. Significant differences were observed and demonstrate the great functionality of predictive modeling to rule out the use of certain nanoparticles to deliver the photosensitizer due to the limited therapeutic effect at certain depths within the carcinoma despite the photosensitizer delivery improvements.
References
D. K. Chatterjee, L. S. Fong, Y. Zhang, "Nanoparticles in photodynamic therapy: An emerging paradigm," Adv. Drug Deliv. Rev 60, 1627-1637 (2008). DOI
F. Scarmato, R. Fonseca, J. A. Thomazine, A. C. Tedesco, N. Lange, M. V. Lopes, "In Vitro Metabolism of 5-ALA Esters Derivatives in Hairless Mice Skin Homogenate and in Vivo PpIX Accumulation Studies," Pharmaceut. Res. 21, 2247-2252 (2004). DOI
H. S. Gill, S. N. Andrews, S. K. Sakthivel, A. Fedanov, I. R. Williams, D. A. Garber, F. H. Priddy, S. Yellin, M. B. Feinberg, S. I. Staprans, M. R. Prausnitz, "Selective removal of stratum corneum by microdermabrasion to increase skin permeability," Eur. J Pharm. Sci. 38, 95–103 (2009). DOI
R. R. Allison, H. C. Mota, V. S. Bagnato, C. H. Sibata, "Bio-nanotechnology and photodynamic therapy-State of the art review," Photodiagn. Photodyn. 5, 19-28 (2008). DOI
M. R. Hamblin, P. Mróz, Advances in Photodynamic Therapy: Basic, Translational and Clinical. Engineering in medicine & Biology (2008).
M. E. Wieder, D. C. Hone, M. J. Cook, M. M. Handsley, J. Gavrilovic, D. A. Russell, "Intracellular photodynamic therapy with photosensitizer-nanoparticle conjugates: cancer therapy using a ‘Trojan horse," Photochem. Photobiol. Sci. 5, 727-734 (2006). DOI
M. K. K. Oo, X. Yang, H. Du, H. Wang, "5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer," Nanomedicine 3, 777-786 (2008). DOI
S. L. Jacques, Monte Carlo Simulations of Fluorescence in Turbid Media, Handbook of Biomedical Fluorescence. B. W. Rogue and M. A. Mycek eds. CRC Press (2003).
X. Xu, A. Meade, Y. Bayazitoglu, "Numerical investigation of nanoparticle-assisted laser-induced interstitial thermotherapy toward tumor and cancer treatments," Lasers Med Sci. 26, 213-222 (2011). DOI
C. F. Bohren, D. R. Huffman, Absorption and Scattering of Light by Small Particles. John Wiley (1983).
C. Mätzler, MATLAB Functions for Mie Scattering and Absorption. Universitas Bernensis (2002).
E. Salomatina, B. Jiang, J. Novak, A. N. Yaroslavsky, "Optical properties of normal and cancerous human skin in the visible and near-infrared spectral range," J. Biomed. Opt. 11, 0640261-640269 (2006). DOI
B. C. Wison, M. S. Patterson, "The physics, biophysics and technology of photodynamic therapy," Phys. Med. Biol. 53, R61–R109 (2008). DOI
I. Salas-García, F. Fanjul-Vélez, N. Ortega-Quijano, A. Lavín-Castanedo, P. Mingo-Ortega, M. López-Escobar, J. L. Arce-Diego, "Effect of gold nanoparticles in the local heating of skin tumors induced by phototherapy," Proc. SPIE 8092, 8092041-7 (2011). DOI